Page 45 - Pharma News Letter Vol1 Issue2 - Converted By Dr. Ahmed Rashed

Research Publications

Effects of early adjunctive pharmacotherapy on serum levels

of brain injury biomarkers in patients with traumatic brain
injury: a systematic review of randomized controlled studies

Noha O. Mansour , Mohamed Hassan systematically searched using predefined
1
Elnaem ,*, Doaa H. Abdelaziz , Muna search terms. English-language randomized
4
2,3
Barakat , Inderpal Singh Dehele , Mahmoud controlled clinical trials reporting changes
5,6
7
E. Elrggal , and Mahmoud S. Abdallah 9 in brain injury biomarkers, namely, neuron-
8
1 Clinical Pharmacy and Pharmacy Practice specific enolase (NSE), glial fibrillary acid
Department, Faculty of Pharmacy, Mansoura protein (GFAP), ubiquitin carboxyl-terminal
University, Mansoura, Egypt. esterase L1 (UCHL1) and/or S100 beta (S100
ß), were included. The methodological quality
2 School of Pharmaceutical Sciences, Universiti of the included studies was assessed using the
Sains Malaysia, Minden, Malaysia. Cochrane risk-of-bias tool.

3 School of Pharmacy and Pharmaceutical Results: A total of eleven studies with eight
Sciences, Ulster University, Coleraine, United different therapeutic options were investigated; of
Kingdom, them, tetracyclines, metformin, and memantine

4 Pharmacy Practice and Clinical Pharmacy were discovered to be promising choices that
Department, Faculty of Pharmacy, Future could improve neurological outcomes in TBI
University in Egypt, Cairo, Egypt, Department patients. The most utilized serum biomarkers
5
of Clinical Pharmacy and Therapeutics, were NSE and S100 ß followed by GFAP, while
Faculty of Pharmacy, Applied Science Private none of the included studies quantified UCHL1.
University, Amman, Jordan, MEU Research The heterogeneity in injury severity categories
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Unit, Middle East University, Amman, Jordan, and measurement timing may affect the overall
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School of Pharmacy, University of Birmingham, evaluation of the clinical efficacy of potential
Birmingham, United Kingdom, College therapies. Therefore, unified measurement
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of Pharmacy, Umm Al- Qura University, protocols are highly warranted to inform clinical
Makkah, Saudi Arabia, Department of Clinical decisions.
9
Pharmacy, Faculty of Pharmacy, University of Conclusion: Few therapeutic options
Sadat City, Sadat City, Egypt showed promising results as an adjuvant to

Abstract standard care in patients with TBI. Several
considerations for future work must be
Objectives: Traumatic brain injury (TBI) is one directed towards standardizing monitoring
of the top causes of morbidity and mortality biomarkers. Investigating the pharmacotherapy
worldwide. The review aimed to discuss effectiveness using a multimodal biomarker
and summarize the current evidence on the panel is needed. Finally, employing stratified
effectiveness of adjuvant neuroprotective randomization in future clinical trials concerning
treatments in terms of their effect on brain injury potential confounders, including age, trauma
biomarkers in TBI patients. severity levels, and type, is crucial to inform

Methods: To identify relevant studies, four clinical decisions. https://doi.org/10.3389/
scholarly databases, including PubMed, fphar.2023.1185277
Cochrane, Scopus, and Google Scholar, were

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