Page 43 - Pharma News Letter Vol1 Issue2 - Converted By Dr. Ahmed Rashed

Research Publications

Natural Product Research

Available online 12 June 2023

New benzaldehyde derivatives from the fruiting bodies of

Hericium erinaceus with cytotoxic activity

Yang Ruan , Chunguang Han1, Dongmei
1
Wang1, Yuka Inoue1, Yhiya Amen , Ahmed
2
Othman , , Yanisa Mittraphab1, Maki Nagata1,
1 3
Kuniyoshi Shimizu1
1 Department of Agro-Environmental
Sciences, Graduate School of Bioresource
and Bioenvironmental Sciences, Kyushu
University, Fukuoka, Japan.
2 Department of Pharmacognosy, Faculty of
Pharmacy, Mansoura University, Mansoura, compounds were isolated from the fruiting
Egypt. bodies of Hericium erinaceus. The chemical
3 Department of Pharmacognosy and Medicinal structures of the isolated compounds were
Plants, Faculty of Pharmacy, Al-Azhar elucidated by using NMR analysis and mass
University, Cairo, Egypt. spectrometry, as well as comparisons with the
reported data in the literature. The bioactivity
Abstract evaluation revealed that hericenone Q showed

Four new natural compounds named hericenone significant cytotoxic activity against Hep-G2
O (1), hericenone P (2), hericenone Q (3), and with IC50 values of 23.89 μM, and against
hericenone R (4), two of them were reported HCT-116 with IC50 values of 65.64 μM.
synthetically (3–4), together with eleven known https://doi.org/10.1080/14786419.2023.216968

7

The Faculty of Pharmacy at Mansoura National University
extends its sincere congratulations and blessings to
Dr.Yhiya Amen, Associate Professor of Pharmacognosy,
Faculty of Pharmacy, Mansoura and Mansoura National
Universities, for ranking from the top 5 scholars of highest
number of published papers in 2022 according to Scopus
metrics, wishing him continued success in his scientific and
practical life.

Vol. 1 - Issue 2 43